Nagesh H. Jayaram, MD

Research Assistant with Professor Asok C.Antony and Prof. H.N. Jayaram, Indiana University School of Medicine, Department of Hematology and Oncology, Indianapolis, IN. Work involved constructing folate-tethered and non-targeted liposomes containing Tiazofurin. liposomes then tested in HD29 and Caco-2 colon cancer cell lines expressing folate receptors. Cytotoxicity studies currently ongoing.

Research with Professor Nasser Hanna, Indiana University School of Medicine, Department of Hematology and Oncology, Indianapolis, IN., involving treatment of extensive Small Cell Lung Cancer. This involved development of a protocol for a randomized, phase II study with Cisplatin plus Etoposide with/without concurrent ZD6474, a novel tyrosine kinase and angiogenesis inhibitor, in patients with previously untreated extensive stage SCLC. Study has funding and protocol is currently pending IRB approval.

Indiana University School of Medicine, Indianapolis, IN
Research Assistant with Prof. Arun Srivastava, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN. Helped in research involving adeno-associated viruses in order to increase the efficiency of gene transfer.

Research Assistant with Prof. H. N. Jayaram, Department of
Biochemistry and Molecular Biology. Research involved elucidation of the mechanism of action of a new anticancer compound, Benzamide Riboside. This work culminated in Co-authorship in a publication.

Research Assistant with Prof. George Weber, Director, Experimental Oncology Laboratory, Indiana University School of Medicine, Indianapolis, IN. Work involved the determination of effect of Tiazofurin, a recent anticancer agent, on IMP dehydrogenase in hepatoma cells.